The current guidelines for evaluating vaccine safety in clinical trials rely primarily on self-reported questionnaires. Despite recent technological advancements, there is a lack of objective and continuous monitoring of physiological changes following vaccination. However, our study has identified significant and continuous alterations in vital signs after vaccination, indicating the potential benefit of continuous monitoring.
Wearable sensors offer a higher level of sensitivity than traditional methods and have the potential to revolutionize clinical trials by allowing earlier detection of adverse reactions with a smaller number of participants. This highlights the need to incorporate continuous physiological monitoring in vaccine safety assessments to improve our understanding of the safety and efficacy of vaccines.
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